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The following is a selection of some of our active studies.

Closed-Loop Interventions – Young and Middle-Aged Adults

The goal of this study is to assess the benefits of Neuroscape interventions (Meditrain, Worder, Coherence, Engage) in healthy young and middle-aged adults using our Nexus platform. A large cohort size will help us understand how individual differences in improvements of aspects of cognitive control, such as attention and working memory, inform intervention-specific effects and pave the way to personalized intervention approaches in the future.
Team: Gallen (co-PI), Zanto (co-PI), Ziegler (co-PI), Ostrand, Volponi,
Funding: McGovern Foundation

Individual Differences – Attention and Adolescents

The goal of this study is to understand how individual variability in attention skills are related to real-world behaviors, such as media multitasking and screen time engagement in teenagers. This will help us understand how improving attention is linked to real-world behaviors in teenagers, ultimately helping us to design better interventions.
Team: Gallen (PI), Volponi,
Funding: UCSF RAP

Immersive Rhythm Training – Learning Differences

The goal of this study is to assess the benefits of rhythm learning with Coherence using a VR head-mounted display in children who have learning differences, such as ADHD and dyslexia. This will help us understand how improving rhythm and temporal attention can lead to real-world benefits.
Team: Gallen (co-PI), Zanto (Co-PI), Collaborators at UCSF Dyslexia Center (Gorno-Tempini, Watson)
Funding: Schwab Dyslexia and Cognitive Diversity Center

Digitally-Delivered Nature – Well-Being

The goal of this study is to assess the potential mental health benefits from exposure to digitally-delivered nature and music in our Sensory Immersion Lab. Additionally, electrophysiological markers collected with our multimodal biosensing system will enable us to understand how brain-body interactions may be altered through nature and music experiences to promote overall well-being.
Team: Zanto (co-PI), Gazzaley (co-PI), Abbasi-Asl, Ziegler, Nandi, Campusano, R. Anguera
Funding: Hanwha

Emotion Sensing – Machine Learning

The goal of this study is to integrate advanced AI and machine learning frameworks with our multimodal biosensing (MMBS) system to decode mental states such as emotion and arousal in human participants. The ability to decode mental states has numerous therapeutic applications that could provide critical insight into the well-being of a patient or enhance the efficacy of a closed-loop intervention.
Team: Abbasi-Asl (PI), Bijanzadeh, Zanto, Ziegler, Wang, Nandi, Campusano, R. Anguera, Gazzaley
Funding: McGovern Foundation

Psilocybin – Meditation

The goal of this study is to assess the potential of a combined psilocybin and digital meditation intervention (Meditrain) to improve emotional well-being in older adults who are lonely. Additionally, electrophysiological, autonomic, and neuroimaging markers will be collected through our multimodal biosensing system, enabling us to understand how brain-body interactions may be altered through these interventions and are affected by loneliness.
Team: Pasquini (PI), Mace, Ostrand, Valtierra
Funding: NIA (R00AG065457), David Dolby and the Dolby Foundation

Navigation – Memory

Labyrinth will be used to study how different types of spatial navigation challenges (virtual reality and tablet-based) result in improved memory and attention in older adults. Findings will also enable us to understand changes in the brain induced by learning navigation tasks.
Team: Wais (PI), Arioli, R. Anguera, Gordon
Funding: Goodman

Meditrain

The goals of this study are to first determine the minimal and/or optimal dose of a meditation-inspired digital intervention (Meditrain) required to improve cognition, and then to examine the impact of potential moderators of treatment effects (i.e., cognitive decline, cardiovascular risk, and race/ethnicity). This knowledge will pave the way for a precision medicine model for interventions in older adults with cognitive deficits who are at risk of developing dementia.
Team: Ziegler (Co-PI), Gazzaley (Co-PI), Wall, Gordon, De Villa
Funding: NIA (R01AG076668)

Meditrain – Brain Stimulation

The goal of this study is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation (transcranial alternating current stimulation (tACS)) and a novel form of closed-loop digital meditation (Meditrain).
Team: Ziegler (Co-PI), Zanto (Co-PI), Gazzaley, Hartley, Chen
Funding: NIA (R61AG080528)

Meditrain – Sleep

The goal of this research is to collect pilot data to test the hypothesis that treatment with a novel form of closed-loop digital meditation (Meditrain) will lead to a greater magnitude of gains in cognitive abilities in patients with mild cognitive impairment (MCI), compared to OA without cognitive impairment, and will also lead to improvements in quantitative measures of sleep.
Team: Ziegler (Co-PI), Walsh (Co-PI), Gazzaley, Patwardhan, Chen
Funding: NIA (R61AG083503)

Psilocybin – Set & Setting

The goal of this study is to assess the contribution of contextual factors (both ‘set’ and ‘setting’) on the nature and trajectory of effects of a single dosing session with psilocybin. Physiological data and subjective evaluations will allow us to determine whether an enriched set and setting interact positively with a psilocybin experience to promote post-session increases in well-being.
Team: Carhart-Harris (PI), Mitchell (Co-PI), Gazzaley, Coker, Miller, Girn, Kettner, Griffith, Yego
Funding: Sarlo, McKnight, Jurvetson, Ferriss, Bedari, Walker, Hearst, Van Almsick

Psilocybin – Internal States

The goal of this study is to identify the neuronal and physiological signatures of distinct sub-states known to occur within psychedelic drug-induced altered states of consciousness: namely, “acceptance vs resistance to feelings”; “positive vs negative feelings” and “no insight to strong insight”. Achieving these goals will have large potential for practical applications, specifically enabling more responsive and adaptive psychedelic therapy protocols.
Team: Carhart-Harris (PI), Pasquini (Co-PI), Gazzaley, Girn, Ostrand, Coker, Rosati, Kettner, Weinstein
Funding: Anonymous

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